Some Pharmacological Actions of ‘nimbidin’- a Bitter Principle of Azadirachta Indica-a Juss (neem)

نویسندگان

  • N.R. Pillai
  • G. Santhakumari
  • Johannes Laping
چکیده

Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihistaminic (H1-receptor), anti 5 HT and antinicotinic activities. But in-vivo tests did not show any anticholinergic or anti-histaminic activity. Nimbidin possessed moderate diuretic activity and was found to be devoid of local anaesthetic and antiandrogenic effects in rodents.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 1984